Journal: Lab Animal
Article Title: Impact of obesity on infarct size, circulating biomarkers, mitochondrial function and mortality in a Göttingen minipig myocardial infarct model
doi: 10.1038/s41684-025-01533-4
Figure Lengend Snippet: a , RR interval. b , QRS duration. c , QT interval. d , QT interval corrected by Fredericia’s formula (QTc). e , Sum of ST elevation. f , MAP. ECG and blood pressure data are missing from one obese animal. In addition, ST elevation and MAP data are missing owing to technical issues in five and three lean animals, respectively. Data are presented as medians and IQR. Linear mixed-model analysis with the individual animal included as random effect. Significant differences between groups are indicated with a black hashtag. Significant differences from baseline values (5 min before occlusion) within individual groups are illustrated with colored asterisks, and when both groups are considered together with a black asterisk. # P < 0.05; * P < 0.05. Data on ST elevation were log-transformed to obtain a better fit with the linear model.
Article Snippet: Furthermore, ECG data from three orthogonal leads (Frank configuration) were recorded on a Quad Bio Amp electrocardiograph switch box with a power lab and LabChart (AD Instruments).
Techniques: Transformation Assay